Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 1/20 | 0.69 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966827 | 0.95 | CCND3 (0.67) | CCND3CDK6PDE10AAURKAJAK2 | |
| SCHEMBL1303899 | 0.93 | CCND3 (0.61) | CCND3CDK6PDE10AAURKAJAK2 | |
| SCHEMBL13042221 | 0.92 | MAPT (0.60) | CCND3CDK6PDE10ANPC1RAB9A | |
| SCHEMBL250171 | 0.90 | CCND3 (0.70) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL9373255 | 0.90 | CCND3 (0.61) | CCND3CDK6PDE10AAURKAJAK2 | |
| Hydrochloric Acid SCHEMBL7000982 | 0.89 | CCND3 (0.68) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL8350123 | 0.89 | CCND3 (0.60) | CCND3CDK6PDE10AAURKAJAK2 | |
| SCHEMBL21759876 | 0.88 | CCND3 (0.56) | CCND3CDK6PDE10ANPC1RAB9A | |
| SCHEMBL10428595 | 0.84 | PDE10A (0.53) | CCND3CDK6PDE10ANPC1RAB9A | |
| SCHEMBL3417204 | 0.82 | CCND3 (0.60) | CCND3CDK6AURKAJAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593476-B2 | Using 2-arylbenzimidazolesulfonic acid | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2003-07-15 | — | — | US | disclosed |