Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 known ✓ | Q00534 | 1/20 | 0.68 |
| ▸ | JAK2 known ✓ | O60674 | 1/20 | 0.61 |
| ▸ | ABL1 known ✓ | P00519 | 1/20 | 0.61 |
| ▸ | NTRK1 known ✓ | P04629 | 1/20 | 0.61 |
| ▸ | LCK known ✓ | P06239 | 1/20 | 0.61 |
| ▸ | CSF1R known ✓ | P07333 | 1/20 | 0.61 |
| ▸ | RET known ✓ | P07949 | 1/20 | 0.61 |
| ▸ | MET known ✓ | P08581 | 1/20 | 0.61 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.61 |
| ▸ | FGFR1 known ✓ | P11362 | 1/20 | 0.61 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.61 |
| ▸ | PRKCQ known ✓ | Q04759 | 1/20 | 0.61 |
| ▸ | ROCK1 known ✓ | Q13464 | 1/20 | 0.61 |
| ▸ | NTRK2 known ✓ | Q16620 | 1/20 | 0.61 |
| ▸ | ALK known ✓ | Q9UM73 | 1/20 | 0.61 |
| ▸ | CCND3 | P30281 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250171 | 0.98 | CCND3 (0.70) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL7199487 | 0.89 | CCND3 (0.69) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL3966827 | 0.87 | CCND3 (0.67) | CCND3CDK6AURKAJAK2ABL1 | |
| Hydrochloric Acid SCHEMBL3808279 | 0.86 | AURKA (0.59) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL3417204 | 0.85 | CCND3 (0.60) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL27576939 | 0.85 | CCND3 (0.64) | CCND3CDK6AURKAJAK2ABL1 | |
| Hydrochloric Acid SCHEMBL2674335 | 0.85 | AURKA (0.58) | CCND3CDK6AURKAJAK2ABL1 | |
| Hydrochloric Acid SCHEMBL5008172 | 0.85 | AURKA (0.58) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL160155 | 0.84 | AURKA (0.61) | CCND3CDK6AURKAJAK2ABL1 | |
| SCHEMBL5358948 | 0.84 | AURKA (0.61) | CCND3CDK6AURKAJAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105722841-A | Novel Heterocyclic Compounds | 卡迪拉保健有限公司 | 2016-06-29 | — | — | CN | claimed |
| CN-103261424-A | Plants with enhanced tolerance to herbicides | BASF SE | 2013-08-21 | — | — | CN | claimed |
| CN-102796057-A | Bis-benzoxazinone compound and preparation method thereof | UNIV SOOCHOW | 2012-11-28 | — | — | CN | claimed |
| CN-107710075-B | Method for manufacturing optical effect layer | 锡克拜控股有限公司 | 2019-11-08 | — | — | CN | disclosed |
| CN-106488839-A | Uniaxial orientation mylar, hardcoat film, touch panel colorimetric sensor films, anti-disperse film, the manufacture method of antireflection film, touch panel and uniaxial orientation mylar | 富士胶片株式会社 | 2017-03-08 | — | — | CN | disclosed |
| CN-104583205-B | Process for producing benzoxazinones | 巴斯夫欧洲公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-104583205-B | Process for producing benzoxazinones | 巴斯夫欧洲公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-104583205-B | Process for producing benzoxazinones | 巴斯夫欧洲公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-103958468-B | Piperidinylnaphthylacetic acids | 弗·哈夫曼-拉罗切有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-106413673-A | Keratin treatment formulations and methods | 利奎德股份有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-103467954-B | A kind of polycarbonate compositions and application thereof | 金发科技股份有限公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-101318981-B | Method for separating benzoxazole oxazinone glycoside compounds from acanthus | SOUTH CHINA SEA INST OCEANOLOG | 2010-12-15 | — | — | CN | disclosed |
| CN-101318981-A | Method for separating benzoxazole oxazinone glycoside compounds from acanthus | SOUTH CHINA SEA INST OCEANOLOG (CN) | 2008-12-10 | — | — | CN | disclosed |
| CN-101151360-A | Emanator blister | RECKITT BENCKISER NV (NL) | 2008-03-26 | — | — | CN | disclosed |
| CN-100349901-C | Anthranilamide insecticides | DU PONT (US) | 2007-11-21 | — | — | CN | disclosed |
| CN-1942613-A | Dyeable polyolefin fibers and fabrics | CIBA SC HOLDING AG (CH) | 2007-04-04 | — | — | CN | disclosed |
| CN-1703417-A | Anthranilamide insecticides | DU PONT (US) | 2005-11-30 | — | — | CN | disclosed |
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | disclosed |
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | disclosed |
| CN-1058395-A | ARYLAMINOCARBONYL COMPOUNDS | SANDOZ LTD (CH) | 1992-02-05 | — | — | CN | disclosed |