Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 1.00 |
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | CCND1 | P24385 | 4/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6897355 | 1.00 | HTR6 (1.00) | HTR6CDK4CCND1ADRA2ACNR1 | |
| SCHEMBL2911126 | 0.96 | HTR6 (0.92) | HTR6CDK4CCND1ADRA2ACNR1 | |
| SCHEMBL30641113 | 0.96 | HTR6 (0.92) | HTR6CDK4CCND1ADRA2ACNR1 | |
| Fumaric Acid SCHEMBL8784881 | 0.89 | HTR6 (0.79) | HTR6CNR1CNR2 | |
| Fumaric Acid SCHEMBL8784884 | 0.89 | HTR6 (0.79) | HTR6CNR1CNR2 | |
| SCHEMBL8530808 | 0.87 | HTR6 (0.77) | HTR6CDK4CCND1ADRA2A | |
| SCHEMBL2267232 | 0.81 | HTR6 (0.67) | HTR6 | |
| SCHEMBL2261753 | 0.81 | HTR6 (0.67) | HTR6 | |
| SCHEMBL7253410 | 0.81 | HTR6 (0.67) | HTR6 | |
| SCHEMBL7253405 | 0.81 | HTR6 (0.67) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102936240-A | Synthetic method of (R)-5-substituted-3-(N-carbobenzoxy pyrrolidine-2-based carbonyl)-1H-benzpyrole | ZHEJIANG ACADEMY MEDICAL SCI | 2013-02-20 | — | — | CN | disclosed |
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |
| US-5607951-A | SEROTONIN AGONIST FOR NERVOUS SYSTEM DISORDERS, ANALGESICS AND PSYCHOTHERAPEUTICS | PFIZER INC (US) | 1997-03-04 | — | — | US | disclosed |