Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202582 | 0.84 | MAPT (0.43) | ENPP2KDM4ETDP1MMP3LMNA | |
| SCHEMBL30336953 | 0.84 | MAPT (0.43) | ENPP2KDM4ETDP1MMP3LMNA | |
| SCHEMBL29609180 | 0.81 | IDO1 (0.52) | ENPP2KDM4ETDP1LMNAHPGD | |
| SCHEMBL2308 | 0.81 | IDO1 (0.52) | ENPP2KDM4ETDP1LMNAHPGD | |
| SCHEMBL3244749 | 0.81 | HTT (0.44) | ENPP2KDM4ETDP1MMP3LMNA | |
| SCHEMBL97716 | 0.80 | MCL1 (0.39) | S1PR1NPC1MCL1PTPN7DUSP3 | |
| SCHEMBL10946217 | 0.80 | PTPN7 (0.37) | S1PR1LMNAMCL1HPGDPTPN7 | |
| SCHEMBL192429 | 0.76 | MAPT (0.38) | ENPP2KDM4ETDP1MMP3LMNA | |
| SCHEMBL1006491 | 0.76 | CSNK2A1 (0.42) | ENPP2KDM4ETDP1MMP3LMNA | |
| SCHEMBL1464835 | 0.76 | TDP1 (0.45) | ENPP2KDM4ETDP1MMP3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| WO-2003042148-A2 | PROCESS FOR PRODUCING BISBENZIL COMPOUNDS | SHOWA DENKO K. K. (JP) | 2003-05-22 | — | — | WO | disclosed |
| US-4144264-A | Process for producing a 3-methyl-2-(4-halophenyl)butyronitrile | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-03-13 | — | — | US | disclosed |