Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.52 |
| ▸ | PNMT | P11086 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609180 | 1.00 | IDO1 (0.52) | IDO1PNMTTAAR1LMNAHPGD | |
| SCHEMBL8189948 | 0.90 | SIGMAR1 (0.50) | IDO1PNMTTAAR1LMNAHPGD | |
| SCHEMBL11682046 | 0.89 | ENPP2 (0.46) | IDO1PNMTTAAR1LMNAHPGD | |
| SCHEMBL28140289 | 0.86 | IDO1 (0.40) | IDO1PNMTTAAR1LMNAHPGD | |
| SCHEMBL24108441 | 0.81 | TRPV4 (0.52) | IDO1ENPP2 | |
| SCHEMBL4711611 | 0.81 | CYP3A4 (0.61) | IDO1PNMTTAAR1LMNAHPGD | |
| SCHEMBL192429 | 0.81 | MAPT (0.38) | IDO1PNMTTAAR1LMNAHPGD | |
| SCHEMBL2125469 | 0.81 | CSNK2A1 (0.42) | IDO1LMNAHPGDENPP2KDM4E | |
| SCHEMBL1464835 | 0.81 | TDP1 (0.45) | LMNAENPP2IGF1RALOX15KDM4E | |
| SCHEMBL15196288 | 0.81 | CA2 (0.52) | LMNAENPP2IGF1RALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 819 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108709944-B | Method for simultaneously detecting 6 chlorobenzene acetonitrile serving as nitrogenous aromatic disinfection by-product in drinking water | 同济大学 | 2021-02-12 | — | — | CN | claimed |
| CN-109613155-A | A kind of detection method of armaticity nitrogenous disinfection byproducts | 同济大学 | 2019-04-12 | — | — | CN | claimed |
| CN-109020837-A | A kind of preparation method of 2- substituted-phenyl-B amidine hydrochloric acid salt | 广东省石油与精细化工研究院 | 2018-12-18 | — | — | CN | claimed |
| US-9527813-B2 | Process for the synthesis of (+) and (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane | EUTHYMICS BIOSCIENCE, INC. (US) | 2016-12-27 | — | — | US | claimed |
| US-20140163240-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | ETHISMOS RESEARCH, INC. | 2014-06-12 | — | — | US | claimed |
| CN-101573034-B | Method for synthesizing (+) and (-) -1- (3, 4-dichlorophenyl) -3-azabicyclo [3.1.0] hexane | DOV PHARMACEUTICAL INC | 2013-01-02 | — | — | CN | claimed |
| US-20120142940-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicycle[3.1.0]Hexane | ETHISMOS RESEARCH, INC. | 2012-06-07 | — | — | US | claimed |
| EP-2061318-B1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-) -1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | DOV PHARMACEUTICAL INC (US) | 2012-03-21 | — | — | EP | claimed |
| US-20110295020-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane | ETHISMOS RESEARCH, INC. | 2011-12-01 | — | — | US | claimed |
| US-20100298574-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane | ETHISMOS RESEARCH, INC. | 2010-11-25 | — | — | US | claimed |
| WO-2007127396-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-) -1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | DOV PHARMACEUTICAL, INC. (US) | 2007-11-08 | — | — | WO | claimed |
| US-6545173-B1 | Chemical intermediate for sibutramine | ABBOTT LABORATORIES | 2003-04-08 | — | — | US | claimed |
| CN-1075057-C | Process for preparing 1-aryl-1-cyanocyclobutane derivatives | KNOLL AG (DE) | 2001-11-21 | — | — | CN | claimed |
| EP-0863868-B1 | PROCESS FOR THE PREPARATION OF 1-ARYL-1-CYANOCYCLOBUTANE DERIVATIVES | KNOLL AG (DE) | 2001-02-21 | — | — | EP | claimed |
| CN-1203585-A | Process for preparation of 1-aryl-1-cyanocyclobutane derivatives | KNOLL AG (DE) | 1998-12-30 | — | — | CN | claimed |
| EP-0863868-A1 | PROCESS FOR THE PREPARATION OF 1-ARYL-1-CYANOCYCLOBUTANE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-09-16 | — | — | EP | claimed |
| WO-1997020810-A1 | PROCESS FOR THE PREPARATION OF 1-ARYL-1-CYANOCYCLOBUTANE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-06-12 | — | — | WO | claimed |
| EP-0612716-B1 | Process for the preparation of an optically pure aminoalcohol | SANOFI SA (FR) | 1996-05-08 | — | — | EP | claimed |
| US-5512680-A | Process for the preparation of an optically pure aminoalcohol | SANOFI (FR) | 1996-04-30 | — | — | US | claimed |
| EP-0612716-A1 | Process for the preparation of an optically pure aminoalcohol | SANOFI (FR) | 1994-08-31 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142940-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicycle[3.1.0]Hexane | ADH1C, DDT, UROD | IDO1 46/4885PNMT 367/4885TAAR1 161/4885 |
| US-20110295020-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane | ADH1C, DDT, UROD | IDO1 41/4885PNMT 311/4885TAAR1 189/4885 |
| US-20140163240-A1 | PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE | ADH1C, DDT, UROD | IDO1 41/4885PNMT 311/4885TAAR1 189/4885 |
| US-20100298574-A1 | Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane | ADH1C, DDT, UROD | IDO1 41/4885PNMT 311/4885TAAR1 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.