SCHEMBL7200117

SCHEMBL7200117

COC(=O)Nc1ccc2[nH]c(C)c(CCNC(C)=O)c2c1.O=C(Cl)C(=O)Cl

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 6/20 0.72
MTNR1A P48039 9/20 0.64
MTNR1B P49286 9/20 0.64
CYP1A2 P05177 2/20 0.59
MEN1 O00255 3/20 0.51
MAPT P10636 3/20 0.51
KMT2A Q03164 3/20 0.51
SPR P35270 1/20 0.51
HTT P42858 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
ALDH1A1 P00352 3/20 0.50
HPGD P15428 3/20 0.50
KDM4E B2RXH2 3/20 0.49
HSD17B10 Q99714 2/20 0.49
GAA P10253 1/20 0.49
PRNP P04156 1/20 0.49
ALOX15 P16050 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6763787 0.96 NQO2 (0.78) NQO2MTNR1AMTNR1BCYP1A2MEN1
SCHEMBL17108183 0.84 NQO2 (1.00) NQO2MTNR1AMTNR1BCYP1A2ALDH1A1
SCHEMBL6765219 0.84 NQO2 (0.76) NQO2MTNR1AMTNR1BCYP1A2ALDH1A1
SCHEMBL6764471 0.80 NQO2 (0.74) NQO2MTNR1AMTNR1BCYP1A2ALDH1A1
SCHEMBL8946916 0.78 MTNR1A (1.00) NQO2MTNR1AMTNR1BCYP1A2MEN1
SCHEMBL31543713 0.78 MTNR1A (1.00) NQO2MTNR1AMTNR1BCYP1A2MEN1
SCHEMBL31543625 0.77 SPR (0.72) NQO2MTNR1AMTNR1BCYP1A2MAPT
SCHEMBL31543676 0.77 SPR (0.72) NQO2MTNR1AMTNR1BCYP1A2MAPT
SCHEMBL18239691 0.77 MTNR1A (0.74) NQO2MTNR1AMTNR1BCYP1A2ALDH1A1
SCHEMBL31543735 0.76 MTNR1A (0.70) NQO2MTNR1AMTNR1BCYP1A2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1307191-A2 USE OF INDOLE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR REDUCING INTRACULAR PRESSURE Inspire Pharmaceuticals, Inc. (US) 2003-05-07 EP disclosed
WO-2002009702-A2 USE OF INDOLE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR REDUCING INTRACULAR PRESSURE INSPIRE PHARMACEUTICALS, INC. (US) 2002-02-07 WO disclosed