Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417143 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL4417138 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL8441891 | 0.95 | ALDH1A1 (0.51) | SMN1; SMN2HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL8441893 | 0.95 | ALDH1A1 (0.51) | SMN1; SMN2HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL6136483 | 0.92 | SMN1; SMN2 (0.60) | SMN1; SMN2HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL4418503 | 0.92 | SMN1; SMN2 (0.60) | SMN1; SMN2HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL6136545 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL4413326 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL14688115 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL9775264 | 0.87 | ALDH1A1 (0.50) | SMN1; SMN2HDAC2HDAC8HDAC6RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030229024-A1 | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | AUDIA JAMES E (US) | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229024-A1 | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | APP, BACE1, IAPP | SMN1; SMN2 1690/4885HDAC2 3690/4885HDAC8 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.