Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800 | 0.95 | CHRM1 (0.41) | CHRM1CHRM2CHRM5CHRM3BRD4 | |
| SCHEMBL7666 | 0.91 | ABCC3 (0.44) | CHRM1CHRM2CHRM5CHRM3POLB | |
| SCHEMBL6973 | 0.87 | BRD4 (0.36) | CHRM1CHRM2CHRM5CHRM3BRD4 | |
| SCHEMBL1127 | 0.86 | LPAR1 (0.43) | CHRM1CHRM2CHRM5CHRM3POLB | |
| SCHEMBL1323 | 0.85 | OPRM1 (0.44) | CHRM1CHRM2CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL1934 | 0.85 | KCNA3 (0.48) | CYP2C9KMT2AMEN1ABCC3ABCC4 | |
| SCHEMBL7026 | 0.84 | AOC3 (0.37) | CHRM1CHRM5CHRM3POLBLMNA | |
| SCHEMBL6605 | 0.83 | ABCC3 (0.38) | CYP2C9ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7532 | 0.82 | ALOX5 (0.35) | CHRM1CHRM2CHRM5CHRM3BRD4 | |
| SCHEMBL2636504 | 0.82 | CHRM2 (0.39) | CHRM1CHRM2BRD4POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |