Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 5/20 | 0.39 |
| ▸ | ADH1C | P00326 | 4/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382413 | 0.98 | ADH1A (0.36) | ADH1AADH1CADH1BDRD2DRD3 | |
| SCHEMBL13397455 | 0.89 | DRD2 (0.33) | DRD2DRD3 | |
| SCHEMBL14355686 | 0.88 | ADH1A (0.37) | ADH1AADH1CADH1BEPHX1DRD2 | |
| SCHEMBL14398636 | 0.82 | KMT2A (0.35) | ADH1AADH1CADH1B | |
| SCHEMBL17914487 | 0.81 | ADH1A (0.47) | ADH1AADH1CADH1BDRD2DRD3 | |
| SCHEMBL22201718 | 0.80 | SLC2A1 (0.38) | ADH1AADH1CEPHX1 | |
| SCHEMBL9927918 | 0.79 | ADH1A (0.44) | ADH1AADH1CADH1BDRD2 | |
| SCHEMBL10251781 | 0.79 | ADH1A (0.39) | ADH1AADH1CADH1B | |
| Hydrochloric Acid SCHEMBL10688333 | 0.79 | ADH1A (0.39) | ADH1AADH1CADH1BTP53 | |
| SCHEMBL736952 | 0.79 | ADH1A (0.39) | ADH1AADH1CADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292604-B1 | 2-AMINOCARBONYL-9H-PURINE DERIVATIVES | PFIZER LTD (GB) | 2009-05-13 | — | — | EP | disclosed |
| US-7414067-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1292604-A1 | 2-AMINOCARBONYL-9H-PURINE DERIVATIVES | Pfizer Limited (GB) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094368-A1 | 2-AMINOCARBONYL-9H-PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-12-13 | — | — | WO | disclosed |