Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.45 |
| ▸ | RAF1 | P04049 | 3/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | GCGR | P47871 | 4/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586451 | 0.87 | MAPK14 (0.51) | MAPK14CSNK1DJAK3TGFBR1MAPK13 | |
| SCHEMBL4584929 | 0.85 | MAPK14 (0.56) | MAPK14CSNK1DJAK3TGFBR1MAPK13 | |
| SCHEMBL4584148 | 0.82 | ALOX5 (0.58) | MAPK14CSNK1DJAK3TGFBR1MAPK13 | |
| SCHEMBL29406707 | 0.81 | TGFBR1 (0.64) | MAPK14CSNK1DJAK3TGFBR1MAPK13 | |
| SCHEMBL7805607 | 0.78 | MAPK14 (0.49) | MAPK14MAPTL3MBTL1 | |
| SCHEMBL4553727 | 0.78 | MAPK14 (0.59) | MAPK14CSNK1DJAK3TGFBR1MAPK13 | |
| SCHEMBL4584932 | 0.78 | MAPK14 (0.46) | MAPK14CSNK1DJAK3TGFBR1MAPK13 | |
| SCHEMBL8120061 | 0.75 | MAPK14 (0.55) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4553285 | 0.75 | ALOX5 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4526549 | 0.74 | TGFBR1 (0.53) | MAPK14CSNK1DTGFBR1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |