Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL1478520 | 1.00 | CYP2A6 (0.61) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Naphthalene SCHEMBL3278833 | 1.00 | CYP2A6 (0.61) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Naphthalene SCHEMBL373901 | 1.00 | CYP2A6 (0.61) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Naphthalene SCHEMBL10590639 | 1.00 | CYP2A6 (0.61) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Naphthalene SCHEMBL27604963 | 0.89 | CYP2A6 (0.57) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Naphthalene SCHEMBL10438031 | 0.88 | CYP2A6 (0.80) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Naphthalene SCHEMBL11145450 | 0.88 | CYP2A6 (0.80) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Anthracene SCHEMBL3911533 | 0.86 | ALDH1A1 (0.56) | ALDH1A1CES2CES1TSHRDAO | |
| Naphthalene SCHEMBL1348831 | 0.86 | CYP2A6 (0.53) | CYP2A6ALOX12ALDH1A1CES2CES1 | |
| Anthracene SCHEMBL29071655 | 0.86 | ALDH1A1 (0.56) | ALDH1A1CES2CES1TSHRDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390673-A1 | METHOD FOR THE PRODUCTION OF SEMI-FINISHED LEATHER OR FUR PRODUCTS | LANXESS Deutschland GmbH (DE) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017102291-A1 | METHOD FOR THE PRODUCTION OF SEMI-FINISHED LEATHER OR FUR PRODUCTS | LANXESS DEUTSCHLAND GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |
| EP-3181707-A1 | METHOD FOR THE MANUFACTURE OF LEATHER OR FUR SEMI-FINISHED PRODUCTS | LANXESS Deutschland GmbH (DE) | 2017-06-21 | — | — | EP | disclosed |
| EP-1304924-A2 | COMPOSITIONS FOR REPELLING CRAWLING INSECTS | Bayer Aktiengesellschaft (DE) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002005646-A2 | COMPOSITIONS FOR REPELLING CRAWLING INSECTS | S.C. JOHNSON & SON, INC. (US) (US) | 2002-01-24 | — | — | WO | disclosed |