Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27521910 | 0.85 | ELANE (0.52) | ELANESMN1; SMN2 | |
| SCHEMBL27502036 | 0.84 | ELANE (0.58) | ELANESMN1; SMN2 | |
| SCHEMBL3052693 | 0.84 | ELANE (0.56) | ELANESMN1; SMN2 | |
| SCHEMBL7011209 | 0.83 | ELANE (0.57) | ELANESMN1; SMN2 | |
| SCHEMBL7011212 | 0.83 | ELANE (0.57) | ELANESMN1; SMN2 | |
| SCHEMBL28743196 | 0.83 | ELANE (0.57) | ELANESMN1; SMN2 | |
| SCHEMBL27561947 | 0.81 | ELANE (0.57) | ELANE | |
| SCHEMBL28743639 | 0.81 | ELANE (0.48) | ELANESMN1; SMN2 | |
| SCHEMBL7511605 | 0.81 | ELANE (0.58) | ELANESMN1; SMN2 | |
| SCHEMBL7199638 | 0.81 | ELANE (0.53) | ELANESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656910-B2 | Serine protease inhibitors | CORTECH, INC. | 2003-12-02 | — | — | US | disclosed |
| US-6656911-B2 | Oxadiazole ring structure peptoids which are useful as inhibitors of serine proteases | CORTECH, INC. | 2003-12-02 | — | — | US | disclosed |
| US-20030203851-A1 | Substituted oxadiazole, peptoids which are useful for treating adult respiratory distress syndrome, septic shock and myocardial ischemia-reperfusion injury | CORTECH, INC. | 2003-10-30 | — | — | US | disclosed |
| US-6608175-B2 | Oxadiazole, thiadiazoles or triazole metal derivatives reacted with an amine containing aldehyde, deprotecting, coupling with an acid and oxidizing to create substituted oxadiazole, thiadiazole or triazole peptoids | CORTECH, INC. | 2003-08-19 | — | — | US | disclosed |
| US-20030060418-A1 | Serine protease inhibitors | CORTECH, INC. | 2003-03-27 | — | — | US | disclosed |
| US-20020119998-A1 | Serine protease inhibitors | CORTECH, INC. | 2002-08-29 | — | — | US | disclosed |
| US-20020119985-A1 | Serine protease inhibitors | CORTECH, INC. | 2002-08-29 | — | — | US | disclosed |
| US-6150334-A | SUBSTITUTED OXADIAZOLE, THIADIAZOLE AND TRIAZOLE STRUCTURES WHICH ARE USEFUL AS INHIBITORS OF SERINE PROTEASES, INCLUDING HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. | 2000-11-21 | — | — | US | disclosed |
| CN-1247542-A | Serine protease inhibitors | CORTECH INC (US) | 2000-03-15 | — | — | CN | disclosed |
| US-6015791-A | Serine protease inhibitors-cycloheptane derivatives | CORTECH INC. (US) | 2000-01-18 | — | — | US | disclosed |
| US-6001811-A | TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPSIS, MULTIPLE ORGAN FAILURE | CORTECH INC. (US) | 1999-12-14 | — | — | US | disclosed |
| US-5998379-A | USEFUL AS INHIBITORS OF SERINE PROTEASES, IN PARTICULAR HUMAN NEUTROPHIL ELASTASE, TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPTIC SHOCK, AND MYOCARDIAL ISCHEMIA-REPERFUSION INJURY | CORTECH INC. (US) | 1999-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119985-A1 | Serine protease inhibitors | PRSS1, SERPINB1, SERPINE1 | ELANE 61/4885SMN1; SMN2 2711/4885 |
| US-20030203851-A1 | Substituted oxadiazole, peptoids which are useful for treating adult respiratory distress syndrome, septic shock and myocardial ischemia-reperfusion injury | TNNI3, PEPD, STK35 | ELANE 127/4885SMN1; SMN2 2650/4885 |
| US-20030060418-A1 | Serine protease inhibitors | PRSS1, SERPINB1, SERPINE1 | ELANE 61/4885SMN1; SMN2 2711/4885 |
| US-20020119998-A1 | Serine protease inhibitors | PRSS1, SERPINB1, SERPINE1 | ELANE 61/4885SMN1; SMN2 2711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.