SCHEMBL7202227

SCHEMBL7202227

Clc1ccc(C2=C([Fe]C3=C(c4ccc(Cl)cc4)C=CC3)CC=C2)cc1

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.38
AHR P35869 1/20 0.34
ALOX5 P09917 1/20 0.32
LMNA P02545 1/20 0.32
CYP2A6 P11509 1/20 0.32
MAOB P27338 1/20 0.31
HDAC2 Q92769 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7195057 0.84
SCHEMBL3952742 0.66 CYP1A2 (0.73) CYP1A2AHRALOX5LMNACYP2A6
SCHEMBL11165087 0.66 CYP1A2 (0.73) CYP1A2AHRALOX5LMNACYP2A6
SCHEMBL28215 0.66 CYP1A2 (0.73) CYP1A2AHRALOX5LMNACYP2A6
SCHEMBL25437316 0.64 CYP1A2 (0.69) CYP1A2AHRALOX5LMNACYP2A6
Hydrogen Sulfide SCHEMBL10394839 0.64 CYP1A2 (0.69) CYP1A2AHRALOX5LMNACYP2A6
Ethyne SCHEMBL29216096 0.61 CYP1A2 (0.65) CYP1A2AHRALOX5LMNACYP2A6
SCHEMBL387589 0.60 CYP1A2 (0.55) CYP1A2AHRALOX5LMNACYP2A6
SCHEMBL3869855 0.60 ALDH1A1 (0.55) CYP1A2AHRALOX5LMNACYP2A6
SCHEMBL9160072 0.59 AHR (0.68) CYP1A2AHRALOX5LMNACYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6656867-B2 Coordination catalyst THE GOODYEAR TIRE & RUBBER COMPANY 2003-12-02 US disclosed
US-20030119662-A1 Transition metal catalysts for diene polymerizations THE GOODYEAR TIRE & RUBBER COMPANY 2003-06-26 US disclosed
US-6479601-B1 Transition metal catalysts for diene polymerizations THE GOODYEAR TIRE & RUBBER COMPANY 2002-11-12 US disclosed