Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208448 | 0.88 | CNR2 (0.38) | MAPTL3MBTL1MAPK14CYP1A2PIK3CA | |
| SCHEMBL7205220 | 0.85 | MAPT (0.40) | MAPTL3MBTL1MAPK14PDE10AMEN1 | |
| SCHEMBL7202373 | 0.81 | MAPT (0.40) | MAPTL3MBTL1MAPK14PDE10AMEN1 | |
| SCHEMBL4584929 | 0.72 | MAPK14 (0.56) | MAPTL3MBTL1MAPK14GCGR | |
| SCHEMBL7207090 | 0.72 | MAPK14 (0.39) | MAPK14CYP1A2PIK3CA | |
| SCHEMBL7202369 | 0.72 | MAPT (0.41) | MAPTL3MBTL1MAPK14PDE10APIK3CA | |
| SCHEMBL7208454 | 0.68 | MAPK14 (0.35) | MAPTL3MBTL1MAPK14MEN1CYP1A2 | |
| SCHEMBL7664199 | 0.66 | MAPT (0.53) | MAPTL3MBTL1MAPK14PDE10AMEN1 | |
| SCHEMBL6621979 | 0.64 | MAPK14 (0.60) | MAPTL3MBTL1MAPK14PDE10AMEN1 | |
| SCHEMBL9124414 | 0.63 | MAPK8 (0.43) | MAPTL3MBTL1MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |