Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PRKCA | P17252 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205220 | 0.88 | MAPT (0.40) | MAPK14PIK3CACYP1A2 | |
| SCHEMBL7208448 | 0.83 | CNR2 (0.38) | MAPK14PIK3CAPRKD3MAP4K4PRKCA | |
| SCHEMBL7208454 | 0.77 | MAPK14 (0.35) | MAPK14PIK3CAPRKD3MAP4K4PRKCA | |
| SCHEMBL7202366 | 0.72 | MAPT (0.42) | MAPK14PIK3CACYP1A2 | |
| SCHEMBL4585785 | 0.71 | ALOX5 (0.64) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL7205342 | 0.70 | MAPK14 (0.42) | MAPK14PIK3CAPRKD3MAP4K4PRKCA | |
| SCHEMBL7202373 | 0.66 | MAPT (0.40) | MAPK14PIK3CACYP1A2 | |
| SCHEMBL6525916 | 0.63 | MAPK14 (0.50) | MAPK14CSNK1A1CSNK1DMAPK13MAPK12 | |
| SCHEMBL27825225 | 0.62 | HRH3 (0.77) | ALOX5 | |
| SCHEMBL7692664 | 0.62 | RPS6KA3 (0.45) | MAPK14PIK3CAPRKD3MAP4K4PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |