Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208454 | 0.88 | MAPK14 (0.35) | MAPTL3MBTL1MAPK14PIK3CABRD4 | |
| SCHEMBL7202366 | 0.81 | MAPT (0.42) | MAPTL3MBTL1MAPK14PIK3CAPDE10A | |
| SCHEMBL7205220 | 0.79 | MAPT (0.40) | MAPTL3MBTL1MAPK14PIK3CAPDE10A | |
| SCHEMBL4584932 | 0.75 | MAPK14 (0.46) | MAPTL3MBTL1MAPK14BRD4BRDT | |
| SCHEMBL7208448 | 0.68 | CNR2 (0.38) | MAPTL3MBTL1MAPK14PIK3CACYP1A2 | |
| SCHEMBL7207090 | 0.66 | MAPK14 (0.39) | MAPK14PIK3CACYP1A2 | |
| SCHEMBL7664199 | 0.64 | MAPT (0.53) | MAPTL3MBTL1MAPK14PIK3CAPDE10A | |
| SCHEMBL7209162 | 0.64 | MAPK14 (0.55) | MAPTMAPK14MEN1ALDH1A1HPGD | |
| SCHEMBL6621979 | 0.62 | MAPK14 (0.60) | MAPTL3MBTL1MAPK14PDE10ABRD4 | |
| SCHEMBL6947142 | 0.62 | MAPK14 (0.64) | MAPK14BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |