Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL825633 | 0.82 | TSHR (0.64) | TSHRNPSR1MAPKAPK2KDM1ADRD1 | |
| SCHEMBL29731083 | 0.82 | TSHR (0.64) | TSHRNPSR1MAPKAPK2KDM1ADRD1 | |
| SCHEMBL15605763 | 0.81 | TSHR (0.62) | TSHRNPSR1MAPKAPK2MAPKAPK5KDM1A | |
| SCHEMBL11024334 | 0.79 | KMT2A (0.40) | TSHRNPSR1SLC6A2SLC6A4TBXA2R | |
| SCHEMBL29381539 | 0.78 | TSHR (0.97) | TSHRNPSR1MAPKAPK2SLC6A2SLC6A4 | |
| SCHEMBL514422 | 0.78 | TSHR (0.97) | TSHRNPSR1MAPKAPK2SLC6A2SLC6A4 | |
| SCHEMBL29597389 | 0.78 | TSHR (0.97) | TSHRNPSR1MAPKAPK2SLC6A2SLC6A4 | |
| SCHEMBL29505877 | 0.78 | TSHR (0.97) | TSHRNPSR1MAPKAPK2SLC6A2SLC6A4 | |
| SCHEMBL574702 | 0.78 | TSHR (0.97) | TSHRNPSR1MAPKAPK2SLC6A2SLC6A4 | |
| SCHEMBL2303831 | 0.78 | TSHR (0.97) | TSHRNPSR1MAPKAPK2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020055637-A1 | Methods for synthesis of amino-tetrahydroisoquinoline-carboxylic acids | PROCTER & GAMBLE COMPANY, THE | 2002-05-09 | — | — | US | claimed |
| US-6608193-B2 | Forming an intermediate by reacting the support-bound amino-substituted-tetrahydroisoquinoline compound with a reagent; and cyclizatively cleaving support-bound amino-substituted-tetrahydroisoquinoline compound | THE PROCTER & GAMBLE COMPANY | 2003-08-19 | — | — | US | disclosed |
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | PROCTER & GAMBLE COMPANY, THE | 2002-06-20 | — | — | US | disclosed |
| US-20020055637-A1 | Methods for synthesis of amino-tetrahydroisoquinoline-carboxylic acids | PROCTER & GAMBLE COMPANY, THE | 2002-05-09 | — | — | US | disclosed |
| EP-0878467-B1 | Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids | HOECHST AG (DE) | 2001-10-31 | — | — | EP | disclosed |
| US-5962471-A | Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-10-05 | — | — | US | disclosed |
| US-5962471-A | Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-10-05 | — | — | US | disclosed |
| EP-0878467-A1 | Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-11-18 | — | — | EP | disclosed |
| CN-1199045-A | Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids | HOECHST AG (DE) | 1998-11-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055637-A1 | Methods for synthesis of amino-tetrahydroisoquinoline-carboxylic acids | DAO, DDC, ASNS | TSHR 4286/4885NPSR1 2776/4885MAPKAPK2 3531/4885 |
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | ASNS, QPCT, DAO | TSHR 4338/4885NPSR1 3091/4885MAPKAPK2 2699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.