Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.69 |
| ▸ | CCR5 | P51681 | 3/20 | 0.69 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.40 |
| ▸ | SPR | P35270 | 4/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961585 | 0.86 | CCR2 (0.74) | CCR2CCR5S1PR1SPRNR3C1 | |
| SCHEMBL5961562 | 0.84 | CCR2 (0.71) | CCR2CCR5S1PR1SPRNR3C1 | |
| SCHEMBL7163174 | 0.83 | CCR2 (0.72) | CCR2CCR5S1PR1SPRNR3C1 | |
| SCHEMBL18841095 | 0.82 | CCR2 (1.00) | CCR2CCR5SPRNR3C1POLB | |
| SCHEMBL2863993 | 0.78 | CCR2 (0.60) | CCR2CCR5S1PR1NR3C1BRAF | |
| SCHEMBL5961584 | 0.76 | CCR2 (0.59) | CCR2CCR5SPRNR3C1POLB | |
| SCHEMBL5961499 | 0.76 | CCR2 (0.59) | CCR2CCR5SPRNR3C1POLB | |
| SCHEMBL7079541 | 0.75 | CCR2 (0.68) | CCR2CCR5SPRNR3C1POLB | |
| SCHEMBL5961458 | 0.73 | CCR2 (0.68) | CCR2CCR5SPRNR3C1POLB | |
| SCHEMBL7079323 | 0.73 | CCR2 (0.66) | CCR2CCR5SPRNR3C1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358188-A2 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK, INC. (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002060900-A2 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK, INC. (US) | 2002-08-08 | — | — | WO | claimed |