Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.59 |
| ▸ | CCR5 | P51681 | 3/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 11/20 | 0.44 |
| ▸ | SPR | P35270 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079541 | 0.82 | CCR2 (0.68) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL5961511 | 0.79 | NR3C1 (0.47) | CCR2CCR5NR3C1 | |
| SCHEMBL5961458 | 0.78 | CCR2 (0.68) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL5961499 | 0.77 | CCR2 (0.59) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL7202793 | 0.76 | CCR2 (0.69) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL5961585 | 0.75 | CCR2 (0.74) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL5961483 | 0.75 | CCR2 (0.66) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL18841095 | 0.75 | CCR2 (1.00) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL5961581 | 0.74 | CCR2 (0.58) | CCR2CCR5NR3C1SPRPOLB | |
| SCHEMBL17980531 | 0.74 | NR3C1 (0.57) | CCR2CCR5NR3C1SPRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670364-B2 | For example (1,3-dimethylpyrazolo(5,4-b)pyridin-5-yl)-N-(((4-fluorophenyl) amino)carbonyl)-carboxamide; useful in prevention or treatment of chronic or acute inflammatory or autoimmune diseases | TELIK, INC. | 2003-12-30 | — | — | US | claimed |
| EP-1358188-A2 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK, INC. (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002060900-A2 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK, INC. (US) | 2002-08-08 | — | — | WO | claimed |
| US-6992086-B2 | Antagonists of MCP-1 function and methods of use thereof | TELIK, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| US-6670364-B2 | For example (1,3-dimethylpyrazolo(5,4-b)pyridin-5-yl)-N-(((4-fluorophenyl) amino)carbonyl)-carboxamide; useful in prevention or treatment of chronic or acute inflammatory or autoimmune diseases | TELIK, INC. | 2003-12-30 | — | — | US | disclosed |