Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | PYGL | P06737 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202948 | 1.00 | MMP9 (0.50) | MMP9MMP8MMP14CAPN1PLG | |
| SCHEMBL7205323 | 0.92 | MMP9 (0.55) | MMP9MMP8MMP14CAPN1PYGL | |
| SCHEMBL7205316 | 0.92 | MMP9 (0.55) | MMP9MMP8MMP14CAPN1PYGL | |
| SCHEMBL7205260 | 0.89 | MMP9 (0.50) | MMP9MMP8MMP14CAPN1PYGL | |
| SCHEMBL7205257 | 0.89 | MMP9 (0.50) | MMP9MMP8MMP14CAPN1PYGL | |
| SCHEMBL7204423 | 0.88 | KMT2A (0.52) | MMP9MMP8MMP14CAPN1ITGA4 | |
| SCHEMBL7204426 | 0.88 | KMT2A (0.52) | MMP9MMP8MMP14CAPN1ITGA4 | |
| SCHEMBL7207193 | 0.88 | F13A1 (0.56) | MMP9MMP8MMP14CAPN1ITGA4 | |
| SCHEMBL14513403 | 0.88 | MMP9 (0.63) | MMP9MMP8MMP14CAPN1PYGL | |
| SCHEMBL7203445 | 0.88 | MMP9 (0.48) | MMP9MMP8MMP14CAPN1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921122-B1 | EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-05-21 | — | — | EP | disclosed |
| US-6110967-A | USEFUL AS AGENTS FOR PREVENTING AND TREATING METABOLIC OSTEOPATHY SUCH AS OSTEOPOROSIS, HYPERCALCEMIA AND BONE METASTASIS OF CANCER BECAUSE THEY SPECIFICALLY INHIBITS CATHEPSIN L AND ITS FAMILY ENZYMES TO INHIBIT BONE RESORPTION | TAIHO PHARMACEUTICALS CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |