Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 16/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567108 | 0.92 | ADORA2A (0.57) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL8092955 | 0.90 | ADORA1 (0.47) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7566398 | 0.90 | ADORA1 (0.47) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7203736 | 0.89 | ADORA2A (0.69) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7456402 | 0.85 | ADORA2A (0.68) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7230915 | 0.85 | ADORA2A (0.68) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7207505 | 0.81 | ADORA2A (0.70) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7208265 | 0.80 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7587828 | 0.79 | ADORA2A (0.57) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7207964 | 0.79 | ADORA2A (0.57) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |