Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | HTR1D | P28221 | 6/20 | 0.44 |
| ▸ | HTR1B | P28222 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208944 | 0.91 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8891818 | 0.89 | HTR1A (0.68) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7509146 | 0.88 | HTR1A (0.67) | HTR1AHTR1DHTR1BDRD2 | |
| Iodide SCHEMBL7510396 | 0.87 | HTR1A (0.65) | HTR1AHTR1DHTR1BDRD2 | |
| Acetic Acid SCHEMBL7515123 | 0.85 | HTR1A (0.66) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7203091 | 0.85 | HTR1A (0.69) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7209681 | 0.83 | HTR1A (0.80) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7514239 | 0.82 | HTR1A (0.74) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL9558592 | 0.80 | HTR1A (0.75) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8889776 | 0.80 | HTR1A (0.83) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471576-B1 | 6-substituted-tetrahydrobenz[cd]indoles | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | claimed |
| US-5229409-A | Antidepressant, tranquilizer | ELI LILLY AND COMPANY (US) | 1993-07-20 | — | — | US | claimed |
| EP-0471576-B1 | 6-substituted-tetrahydrobenz[cd]indoles | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5229409-A | Antidepressant, tranquilizer | ELI LILLY AND COMPANY (US) | 1993-07-20 | — | — | US | disclosed |