SCHEMBL7203728

SCHEMBL7203728

CC(C)(C)OC(=O)N1CCC(SC(=O)c2ccccc2)C1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.54
PKM P14618 1/20 0.54
GPR119 Q8TDV5 3/20 0.53
USP30 Q70CQ3 5/20 0.53
HPGDS O60760 3/20 0.49
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
JAK2 O60674 1/20 0.48
JAK1 P23458 1/20 0.48
CCR8 P51685 1/20 0.46
KEAP1 Q14145 1/20 0.46
NFE2L2 Q16236 1/20 0.46
STS P08842 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6398075 1.00 KDM4E (0.54) KDM4EPKMGPR119USP30HPGDS
SCHEMBL21640298 0.89 KDM4E (0.49) KDM4EPKMGPR119USP30HPGDS
SCHEMBL26301615 0.85 KDM4E (0.50) KDM4EPKMGPR119USP30HPGDS
SCHEMBL6397687 0.81 ACHE (0.54) KDM4EMEN1KMT2A
SCHEMBL6397681 0.81 ACHE (0.54) KDM4EMEN1KMT2A
SCHEMBL26301875 0.81 KDM4E (0.50) KDM4EPKMGPR119USP30HPGDS
SCHEMBL389329 0.80 GPR119 (0.56) GPR119KEAP1NFE2L2
SCHEMBL27400480 0.80 KDM4E (0.46) KDM4EPKMGPR119USP30HPGDS
SCHEMBL26301614 0.79 KDM4E (0.44) KDM4EPKMGPR119USP30HPGDS
SCHEMBL21848120 0.79 KDM4E (0.56) KDM4EPKMGPR119USP30MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757051-B1 PENEM DERIVATIVES AND ANTIMICROBIAL AGENT CONTAINING THE SAME DAIICHI SUNTORY PHARMA CO LTD (JP) 2003-10-29 EP disclosed
EP-0757051-A1 PENEM DERIVATIVES AND ANTIMICROBIAL AGENT CONTAINING THE SAME SUNTORY LIMITED (JP) 1997-02-05 EP disclosed