Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203838 | 0.78 | MEN1 (0.39) | POLBGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL18300976 | 0.75 | MAP2K1 (0.41) | KDM4EALDH1A1MAP2K1SLC6A2SLC6A4 | |
| SCHEMBL30441601 | 0.73 | GAA (0.72) | POLBGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL1162713 | 0.73 | GAA (0.72) | POLBGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL669346 | 0.71 | SMN1; SMN2 (0.57) | POLBGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL12100931 | 0.71 | POLB (0.54) | POLBGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL30926124 | 0.71 | ESR2 (0.42) | GAAMAP2K1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL3401714 | 0.71 | ESR2 (0.42) | GAAMAP2K1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL523138 | 0.69 | SMN1; SMN2 (0.62) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3421682 | 0.69 | CDC7 (0.38) | GAASMN1; SMN2MAPTMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610726-B2 | Pyrazole derivative that mimics or agonizes hepatocyte growth factor/scatter factor; antiischemic agents | NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE | 2003-08-26 | — | — | US | disclosed |