Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379349 | 0.98 | TDP1 (0.41) | LMNAGAATDP1NAAAKIF11 | |
| SCHEMBL11750822 | 0.81 | LMNA (0.40) | LMNAGAATDP1NAAAKIF11 | |
| SCHEMBL28494111 | 0.80 | TDP1 (0.41) | LMNAGAATDP1NAAAKIF11 | |
| SCHEMBL28866690 | 0.80 | EGFR (0.42) | LMNAGAATDP1NAAAKIF11 | |
| SCHEMBL28136728 | 0.80 | EGFR (0.42) | LMNAGAATDP1NAAAKIF11 | |
| SCHEMBL23234253 | 0.80 | SIGMAR1 (0.36) | LMNAGAAKIF11SIGMAR1EGFR | |
| SCHEMBL28147087 | 0.80 | EGFR (0.42) | LMNAGAATDP1NAAAKIF11 | |
| SCHEMBL4414522 | 0.80 | LMNA (0.39) | LMNAGAATDP1NAAAKIF11 | |
| SCHEMBL10440076 | 0.79 | BCL2 (0.53) | LMNAGAASIGMAR1 | |
| SCHEMBL1148767 | 0.78 | KCNN4 (0.40) | LMNAKIF11ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002030882-A9 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS INC (US) | 2003-02-20 | — | — | WO | claimed |