Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.32 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204439 | 1.00 | LMNA (0.40) | LMNAMAPTMGAT2GAASMN1; SMN2 | |
| SCHEMBL7210601 | 0.99 | LMNA (0.39) | LMNAMAPTMGAT2GAASMN1; SMN2 | |
| SCHEMBL7210604 | 0.99 | LMNA (0.39) | LMNAMAPTMGAT2GAASMN1; SMN2 | |
| SCHEMBL7204672 | 0.85 | LMNA (0.40) | LMNAMAPTGAASMN1; SMN2KDM4E | |
| SCHEMBL7204675 | 0.85 | LMNA (0.40) | LMNAMAPTGAASMN1; SMN2KDM4E | |
| SCHEMBL7211279 | 0.85 | LMNA (0.37) | LMNAMAPTMGAT2GAASMN1; SMN2 | |
| SCHEMBL7208986 | 0.84 | LMNA (0.40) | LMNAMAPTGAASMN1; SMN2KDM4E | |
| SCHEMBL7208983 | 0.84 | LMNA (0.40) | LMNAMAPTGAASMN1; SMN2KDM4E | |
| SCHEMBL4807360 | 0.83 | LSS (0.43) | LMNAMAPTMGAT2GAASMN1; SMN2 | |
| SCHEMBL4807352 | 0.83 | LSS (0.43) | LMNAMAPTMGAT2GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |