Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208986 | 1.00 | LMNA (0.40) | LMNAMAPTCARM1PRMT6SMN1; SMN2 | |
| SCHEMBL7204675 | 0.99 | LMNA (0.40) | LMNAMAPTCARM1PRMT6SMN1; SMN2 | |
| SCHEMBL7204672 | 0.99 | LMNA (0.40) | LMNAMAPTCARM1PRMT6SMN1; SMN2 | |
| SCHEMBL7208602 | 0.85 | LMNA (0.41) | LMNAMAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL7208600 | 0.85 | LMNA (0.41) | LMNAMAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL7210604 | 0.85 | LMNA (0.39) | LMNAMAPTSMN1; SMN2KDM4EGAA | |
| SCHEMBL7210601 | 0.85 | LMNA (0.39) | LMNAMAPTSMN1; SMN2KDM4EGAA | |
| SCHEMBL7204439 | 0.84 | LMNA (0.40) | LMNAMAPTSMN1; SMN2KDM4EGAA | |
| SCHEMBL7204442 | 0.84 | LMNA (0.40) | LMNAMAPTSMN1; SMN2KDM4EGAA | |
| SCHEMBL4799620 | 0.83 | LSS (0.52) | LMNAMAPTSMN1; SMN2MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |