Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587966 | 0.88 | LMNA (0.54) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL5672145 | 0.84 | LMNA (0.52) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL7877720 | 0.84 | LMNA (0.52) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL18662883 | 0.81 | LMNA (0.52) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL7135801 | 0.80 | LMNA (0.49) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL7137249 | 0.79 | LMNA (0.48) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL4220943 | 0.79 | LMNA (0.52) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL4218774 | 0.79 | LMNA (0.52) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL7136967 | 0.79 | LMNA (0.48) | LMNAMAPTNR3C1PGRNR1I2 | |
| SCHEMBL30915294 | 0.79 | LMNA (0.48) | LMNAMAPTCYP19A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610675-B1 | Identifying nontoxic therapeutically inactive metabolite of drug which elicits particular therapeutic response, converting inactive metabolite into activated structurally related drug species which cleaves in vivo to inactive metabolite | Bodor, Nicholas S. | 2003-08-26 | — | — | US | disclosed |