SCHEMBL720476

SCHEMBL720476

N=C(Nc1ccccc1)N(S)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS2R38 P59533 3/20 0.40
HSD17B10 Q99714 3/20 0.40
TP53 P04637 2/20 0.40
TSHR P16473 2/20 0.40
ALDH1A1 P00352 2/20 0.40
EPHX2 P34913 2/20 0.40
EPHX1 P07099 1/20 0.40
CDK9 P50750 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CLK4 Q9HAZ1 1/20 0.40
CYP3A4 P08684 1/20 0.40
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
MITF O75030 1/20 0.39
PAX8 Q06710 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
NOX1 Q9Y5S8 2/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalic Acid SCHEMBL11540832 0.88 ALDH1A1 (0.53) HSD17B10TP53TSHRALDH1A1EPHX2
SCHEMBL109209 0.79 ALDH1A1 (0.43) TAS2R38HSD17B10TP53TSHRALDH1A1
SCHEMBL1792956 0.79 ALDH1A1 (0.43) TAS2R38HSD17B10TP53TSHRALDH1A1
SCHEMBL1815230 0.78 HSD17B10 (0.47) TAS2R38HSD17B10TP53TSHRALDH1A1
Hydrochloric Acid SCHEMBL3143822 0.78 ALDH1A1 (0.41) TAS2R38HSD17B10TP53TSHRALDH1A1
SCHEMBL5353973 0.76 MEN1 (0.56) HSD17B10TP53TSHRALDH1A1EPHX2
SCHEMBL6049094 0.76 MEN1 (0.42) TAS2R38HSD17B10TP53TSHRALDH1A1
SCHEMBL7528801 0.76 HSD17B10 (0.40) TAS2R38HSD17B10TP53TSHRALDH1A1
SCHEMBL5961424 0.76 ALDH1A1 (0.42) TAS2R38HSD17B10TP53TSHRALDH1A1
SCHEMBL9113008 0.76 HTT (0.49) TAS2R38HSD17B10ALDH1A1EPHX2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2990436-B1 RUBBER COMPOSITION PREPARED WITH PRE-TREATED SILICA AND TIRE GOODYEAR TIRE & RUBBER (US) 2018-08-01 EP claimed
US-20160264768-A1 RUBBER PREPARED WITH PRE-TREATED PRECIPITATED SILICA AND TIRE WITH COMPONENT GOODYEAR TIRE & RUBBER COMPANY, THE 2016-09-15 US claimed
EP-2990436-A1 RUBBER COMPOSITION PREPARED WITH PRE-TREATED SILICA AND TIRE The Goodyear Tire & Rubber Company (US) 2016-03-02 EP claimed
US-20160053071-A1 RUBBER PREPARED WITH PRE-TREATED PRECIPITATED SILICA AND TIRE WITH COMPONENT GOODYEAR TIRE & RUBBER COMPANY, THE 2016-02-25 US claimed
US-11547174-B2 Footwear and rubber sole containing dual silica moieties THE GOODYEAR TIRE & RUBBER COMPANY (US) 2023-01-10 US disclosed
EP-3034328-B1 RUBBER COMPOSITION CONTAINING TWO DIFFERENTELY FUNCTIONALISED SBR GOODYEAR TIRE & RUBBER (US) 2022-09-14 EP disclosed
EP-3686031-B1 RUBBER COMPOSITION CONTAINING A SPECIALIZED STYRENE/BUTADIENE ELASTOMER, VEGETABLE OIL AND A TRACTION RESIN GOODYEAR TIRE & RUBBER (US) 2022-03-30 EP disclosed
US-10961373-B2 Tire with tread of carbon black reinforced rubber composition containing specialized styrene/butadiene elastomer THE GOODYEAR TIRE & RUBBER COMPANY (US) 2021-03-30 US disclosed
EP-3418073-B1 RUBBER COMPOSITION CONTAINING STYRENE/BUTADIENE ELASTOMER AND SILICA REINFORCEMENT AND TIRE GOODYEAR TIRE & RUBBER (US) 2020-08-05 EP disclosed
EP-3686031-A1 RUBBER COMPOSITION CONTAINING A SPECIALIZED STYRENE/BUTADIENE ELASTOMER, VEGETABLE OIL AND A TRACTION RESIN The Goodyear Tire & Rubber Company (US) 2020-07-29 EP disclosed
US-20200231787-A1 TIRE WITH COMPONENT OF SILICA REINFORCED RUBBER COMPOSITION CONTAINING SPECIALIZED STYRENE/BUTADIENE ELASTOMER AND VEGETABLE OIL AND TRACTION RESIN GOODYEAR TIRE & RUBBER COMPANY, THE 2020-07-23 US disclosed
US-20200146394-A1 FOOTWEAR AND RUBBER SOLE CONTAINING DUAL SILICA MOIETIES THE GOODYEAR TIRE & RUBBER COMPANY 2020-05-14 US disclosed
US-7956146-B2 Tire with tread of polybutadiene rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 2011-06-07 US disclosed
EP-2223928-A1 Functionalized lignin, rubber containing functionalized lignin and products containing such rubber composition The Goodyear Tire & Rubber Company (US) 2010-09-01 EP disclosed
US-20100216939-A1 TIRE WITH TREAD OF POLYBUTADIENE RUBBER GOODYEAR TIRE & RUBBER COMPANY, THE 2010-08-26 US disclosed
EP-2221195-A1 Tire with a rubber composition and a tread of polybutadiene rubber The Goodyear Tire & Rubber Company (US) 2010-08-25 EP disclosed
US-20100204368-A1 FUNCTIONALIZED LIGNIN, RUBBER CONTAINING FUNCTIONALIZED LIGNIN AND PRODUCTS CONTAINING SUCH RUBBER COMPOSITION NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC 2010-08-12 US disclosed
US-7473728-B2 Dual phase rubber composition and tire with nanocomposite-containing sidewall thereof THE GOODYEAR TIRE & RUBBER COMPANY (US) 2009-01-06 US disclosed
US-20060135671-A1 Dual phase rubber composition and tire with nanocomposite-containing sidewall thereof GOODYEAR TIRE & RUBBER COMPANY, THE 2006-06-22 US disclosed
US-4603712-A Compounded polychloroprene formulation used as an adhesive layer in the manufacture of elastomeric articles THE GATES RUBBER COMPANY (US) 1986-08-05 US disclosed