Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | CPN1 | P15169 | 2/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL3054588 | 0.99 | PTGS1 (0.39) | PTGS1SLC7A11SLC7A5CPN1CPB2 | |
| Valine SCHEMBL7646500 | 0.97 | PTGS1 (0.42) | PTGS1SLC7A11SLC7A5CPN1CPB2 | |
| Valine SCHEMBL28182158 | 0.97 | PTGS1 (0.42) | PTGS1SLC7A11SLC7A5CPN1CPB2 | |
| Valine SCHEMBL28182157 | 0.97 | PTGS1 (0.42) | PTGS1SLC7A11SLC7A5CPN1CPB2 | |
| Valine SCHEMBL27660752 | 0.97 | PTGS1 (0.42) | PTGS1SLC7A11SLC7A5CPN1CPB2 | |
| Valine SCHEMBL5666087 | 0.95 | PTGS1 (0.36) | PTGS1SLC7A11SLC7A5CPN1CPB2 | |
| Valine SCHEMBL28189265 | 0.95 | PTGS1 (0.36) | PTGS1SLC7A11SLC7A5CPN1CPB2 | |
| Valine SCHEMBL6368984 | 0.94 | PTGS1 (0.36) | PTGS1SLC7A11SLC7A5 | |
| Proline SCHEMBL7204958 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2PRCP | |
| Asparagine SCHEMBL5665078 | 0.93 | PTGS1 (0.35) | PTGS1SLC7A11SLC7A5CPN1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666842-B2 | Elastin peptide analogs and uses thereof | Connective Tissue Imagineering, LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-20050054578-A1 | Elastin peptide analogs and uses thereof | SANDBERG LAWRENCE B (US) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054578-A1 | Elastin peptide analogs and uses thereof | ELANE, CUTA, ENPEP | PTGS1 1903/4885SLC7A11 3769/4885SLC7A5 2652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.