Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.59 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863330 | 0.90 | ELANE (0.70) | ELANECASP1 | |
| SCHEMBL7212233 | 0.87 | ELANE (0.60) | ELANECASP1 | |
| SCHEMBL8200206 | 0.81 | ELANE (0.39) | ELANECASP1CASP3 | |
| SCHEMBL7208083 | 0.80 | ELANE (0.68) | ELANECASP1 | |
| SCHEMBL6556446 | 0.79 | ELANE (0.69) | ELANE | |
| SCHEMBL6556086 | 0.78 | ELANE (0.80) | ELANE | |
| SCHEMBL27551178 | 0.76 | ELANE (0.71) | ELANECASP1 | |
| SCHEMBL7210360 | 0.76 | ELANE (0.66) | ELANE | |
| SCHEMBL7863335 | 0.76 | ELANE (0.45) | ELANECASP1 | |
| SCHEMBL6801541 | 0.75 | CASP1 (0.59) | CASP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752987-B1 | PYRIMIDINYL DERIVATIVES AS INTERLEUKIN INHIBITORS | VERTEX PHARMA (US) | 2003-11-12 | — | — | EP | claimed |
| US-6162800-A | ENZYME INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-12-19 | — | — | US | claimed |
| EP-0752987-B1 | PYRIMIDINYL DERIVATIVES AS INTERLEUKIN INHIBITORS | VERTEX PHARMA (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |
| US-6162800-A | ENZYME INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-12-19 | — | — | US | disclosed |
| US-5670494-A | N-(pyrimidinyl)-aspartic acid analogs as interleukin-1β converting enzyme inhibitors | SANOFT | 1997-09-23 | — | — | US | disclosed |