Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366788 | 0.87 | SPHK2 (0.42) | SPHK2SPHK1MEN1KMT2ACD274 | |
| SCHEMBL14027308 | 0.85 | SPHK2 (0.44) | FAAHSPHK2SPHK1MEN1KMT2A | |
| SCHEMBL4361737 | 0.85 | SPHK2 (0.44) | FAAHSPHK2SPHK1MEN1KMT2A | |
| SCHEMBL14027306 | 0.85 | SPHK2 (0.44) | FAAHSPHK2SPHK1MEN1KMT2A | |
| SCHEMBL5767465 | 0.85 | FAAH (0.44) | FAAHSPHK2SPHK1MEN1KMT2A | |
| SCHEMBL4370884 | 0.82 | FAAH (0.48) | FAAHSPHK2SPHK1CD274PDCD1LG2 | |
| Formic Acid SCHEMBL4908786 | 0.81 | SPHK2 (0.42) | SPHK2SPHK1MEN1KMT2ACD274 | |
| SCHEMBL14027638 | 0.77 | FAAH (0.44) | FAAHMEN1KMT2AMC4RCCR5 | |
| SCHEMBL4307265 | 0.77 | FAAH (0.44) | FAAHMEN1KMT2AMC4RCCR5 | |
| SCHEMBL14027317 | 0.77 | FAAH (0.44) | FAAHMEN1KMT2AMC4RCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363890-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2003-11-26 | — | — | EP | claimed |
| WO-2002062766-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-08-15 | — | — | WO | claimed |
| EP-1363890-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002062766-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-08-15 | — | — | WO | disclosed |