Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.91 |
| ▸ | HPGD | P15428 | 5/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL28088933 | 0.98 | KDM4E (0.86) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL6249450 | 0.97 | KDM4E (0.95) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL546852 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL7738091 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL2511998 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL458273 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL1026592 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL9981 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL3132735 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL11514957 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6042848-A | FOR CONTROLLING GROWTH OF UNDESIRABLE OR PATHOGENIC MICROORGANISMS IN VARIOUS LOCI OR MILIEU IN, ON, OR OUTSIDE THE BODY EMPLOYING ANTIMICROBIAL PEPTIDES AND METAL IONS | THE BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (US) | 2000-03-28 | — | — | US | claimed |
| EP-0920327-A1 | ENHANCEMENT OF ANTIMICROBIAL PEPTIDE ACTIVITY BY METAL IONS | Southern Illinois University (US) | 1999-06-09 | — | — | EP | claimed |
| WO-1998006419-A1 | ENHANCEMENT OF ANTIMICROBIAL PEPTIDE ACTIVITY BY METAL IONS | SOUTHERN ILLINOIS UNIVERSITY (US) | 1998-02-19 | — | — | WO | claimed |
| EP-0004570-B1 | THIOL ESTERS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS USING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-04-14 | — | — | EP | claimed |
| EP-0004570-A1 | Thiol esters, process for their preparation, pharmaceutical compositions containing them and a process for preparing cephalosporin compounds using the same | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1979-10-17 | — | — | EP | claimed |
| EP-2709714-B1 | APPARATUS FOR HEATING A TREATMENT REGION WITH AN ALTERNATING ELECTRIC FIELD | INNOVOLINK LLC (US) | 2019-01-16 | — | — | EP | disclosed |
| US-9956028-B2 | Apparatus and method for heating biological targets | INNOVOLINK, LLC (US) | 2018-05-01 | — | — | US | disclosed |
| US-9901387-B2 | Apparatus and method for heating adipose cells | INNOVOLINK, LLC (US) | 2018-02-27 | — | — | US | disclosed |
| US-9901742-B2 | Apparatus and method for heating a treatment region with an alternating electric field | INNOVOLINK, LLC (US) | 2018-02-27 | — | — | US | disclosed |
| US-9675814-B2 | Apparatus and method for obtaining a substantially constant current across a treatment region | INNOVOLINK, LLC (US) | 2017-06-13 | — | — | US | disclosed |
| US-20150309434-A1 | POLYMER PARTICLES AND METHOD FOR PRODUCING A THREE-DIMENSIONAL STRUCTURE THEREFROM BY MEANS OF AN ELECTROGRAPHIC METHOD | Universität Stuttgart (DE) | 2015-10-29 | — | — | US | disclosed |
| US-9098000-B2 | Process of making a three-dimensional structure on a support structure | FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2015-08-04 | — | — | US | disclosed |
| WO-1998006419-A1 | ENHANCEMENT OF ANTIMICROBIAL PEPTIDE ACTIVITY BY METAL IONS | SOUTHERN ILLINOIS UNIVERSITY (US) | 1998-02-19 | — | — | WO | disclosed |
| US-4767704-A | CULTIVATING HYBRIDOMAS; TRACE ELEMENTS, INORGANIC SALTS AND BASAL MEDIUM | COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1988-08-30 | — | — | US | disclosed |
| US-4639308-A | RECYCLING GASES AFTER REMOVAL OF OLEFINS | PHILLIPS PETROLEUM COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| EP-0004570-B1 | THIOL ESTERS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS USING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-04-14 | — | — | EP | disclosed |
| US-4314059-A | Process for preparing cephalosporin compounds | SHIBUYA CHISEI | 1982-02-02 | — | — | US | disclosed |
| US-4258195-A | Novel thiol esters and process for preparing cephalosporin compounds using same | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-03-24 | — | — | US | disclosed |
| US-4226792-A | BALLISTICS PROPELLANT ADDITIVE | NL INDUSTRIES, INC. (US) | 1980-10-07 | — | — | US | disclosed |
| EP-0004570-A1 | Thiol esters, process for their preparation, pharmaceutical compositions containing them and a process for preparing cephalosporin compounds using the same | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1979-10-17 | — | — | EP | disclosed |