Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205506 | 0.87 | ESR1 (0.57) | ESR2MEN1KMT2AESR1GRM2 | |
| SCHEMBL7204491 | 0.84 | MEN1 (0.50) | ESR2MEN1NPC1KMT2ASYK | |
| SCHEMBL7205374 | 0.79 | ESR2 (0.63) | ESR2ESR1KDM4EALDH1A1HPGD | |
| SCHEMBL4090955 | 0.75 | HSD17B1 (0.59) | MEN1NPC1KMT2ASYKAURKB | |
| SCHEMBL4085836 | 0.72 | HSD17B1 (0.64) | MEN1KMT2ASYKBACE1CYP1A2 | |
| SCHEMBL13486839 | 0.69 | CYP1A2 (0.60) | MEN1NPC1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL13408700 | 0.68 | ACACA (0.59) | NPC1AURKBBACE1CYP1A2CYP3A4 | |
| SCHEMBL27751282 | 0.68 | SYK (0.54) | MEN1NPC1KMT2ASYKAURKB | |
| SCHEMBL5147123 | 0.68 | SYK (0.51) | MEN1NPC1KMT2ASYKAURKB | |
| SCHEMBL5142555 | 0.68 | CYP2C19 (0.58) | MEN1NPC1KMT2ASYKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599921-B2 | Antiproliferative agents against estrogen-dependent cancer cells dibenzothiopyran, dibenzopyran and phenanthrene derivatives | NANODESIGN, INC. (CA) | 2003-07-29 | — | — | US | disclosed |
| US-20020156077-A1 | Non-steroidal estrogen receptor ligands | PALOMA PHARMACEUTICALS, INC. | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156077-A1 | Non-steroidal estrogen receptor ligands | ESRRA, ESRRB, ESRRG | ESR2 4/4885MEN1 3581/4885NPC1 2894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.