Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.51 |
| ▸ | MMP1 | P03956 | 15/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 9/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207157 | 0.87 | MMP13 (0.56) | MMP13MMP1ADAMTS4ADAM17MMP2 | |
| SCHEMBL7203046 | 0.85 | MMP1 (0.54) | MMP13MMP1ADAMTS4ADAM17MMP2 | |
| SCHEMBL7201281 | 0.85 | MMP13 (0.52) | MMP13MMP1ADAMTS4ADAM17MMP2 | |
| SCHEMBL7202616 | 0.84 | MMP13 (0.47) | MMP13MMP1ADAMTS4ADAM17MMP9 | |
| SCHEMBL7206537 | 0.84 | MMP13 (0.69) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7204237 | 0.83 | MMP13 (0.51) | MMP13MMP1ADAMTS4ADAM17MMP2 | |
| SCHEMBL7199689 | 0.82 | MMP13 (0.55) | MMP13MMP1ADAMTS4MMP2MMP9 | |
| SCHEMBL7204537 | 0.82 | MMP1 (0.56) | MMP13MMP1ADAMTS4ADAM17MMP2 | |
| SCHEMBL7204557 | 0.82 | MMP13 (0.69) | MMP13MMP1ADAMTS4ADAM17MMP2 | |
| SCHEMBL7203056 | 0.82 | MMP13 (0.58) | MMP13MMP1ADAMTS4ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608104-B2 | Antiarthritic agents; anticancer agents | PFIZER INC | 2003-08-19 | — | — | US | disclosed |
| EP-1138680-A1 | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |