Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30664496 | 1.00 | PTGS2 (0.57) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL29672905 | 0.87 | PTGS2 (0.67) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL7180542 | 0.87 | PTGS2 (0.67) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL31608568 | 0.85 | CYP11B2 (0.65) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL29606538 | 0.85 | PTGS2 (0.65) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL7172726 | 0.85 | PTGS2 (0.65) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL319265 | 0.85 | CYP11B2 (0.65) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| SCHEMBL31666281 | 0.84 | CYP11B2 (0.62) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL17835934 | 0.84 | PTGS2 (0.62) | PTGS2CYP11B2CYP11B1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL29672906 | 0.84 | PTGS2 (0.62) | PTGS2CYP11B2CYP11B1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300376-B1 | FOR THERAPY TO ACHIEVE SMOOTH MUSCLE RELAXING ACTIVITY AND/OR MAST CELL STABILIZING ACTIVITY AND/OR ANTI-INFLAMMATORY ACTIVITY | VENANTIUS LIMITED (IR) | 2001-10-09 | — | — | US | claimed |
| CN-104093749-B | Catalyst composition and process for preparing the same | 沙特基础工业公司 | 2018-08-07 | — | — | CN | disclosed |
| CN-1139573-C | Fused isoindolones as inhibitors of protein kinase C | ����˹���ʹ�˾ | 2004-02-25 | — | — | CN | disclosed |
| EP-0871612-B1 | FUSED ISOINDOLONES AS INHIBITORS OF PROTEIN KINASE C | CEPHALON INC (US) | 2003-03-12 | — | — | EP | disclosed |
| CN-1224417-A | Fused isoindolones as inhibitors of protein kinase C | CEPHALON INC (US) | 1999-07-28 | — | — | CN | disclosed |
| EP-0871612-A1 | FUSED ISOINDOLONES AS INHIBITORS OF PROTEIN KINASE C | CEPHALON, INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5808060-A | Fused isoindolones | CEPHALON, INC. (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997021677-A9 | FUSED ISOINDOLONES AS INHIBITORS OF PROTEIN KINASE C | — | 1998-07-23 | — | — | WO | disclosed |
| WO-1997021677-A1 | FUSED ISOINDOLONES AS INHIBITORS OF PROTEIN KINASE C | CEPHALON, INCORPORATED (US) | 1997-06-19 | — | — | WO | disclosed |