Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | EDNRB | P24530 | 4/20 | 0.35 |
| ▸ | EDNRA | P25101 | 4/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.35 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.35 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379 | 0.82 | GAA (0.39) | LPAR1LPAR3BRD4NPY2RALDH1A1 | |
| SCHEMBL1464 | 0.79 | GAA (0.38) | LPAR1LPAR3EDNRBEDNRANPY2R | |
| SCHEMBL1476 | 0.76 | LPAR1 (0.43) | LPAR1LPAR3BRD4ALDH1A1CYP2C9 | |
| SCHEMBL7205 | 0.76 | BRD4 (0.40) | POLBBRD4BRD2BRD3EDNRB | |
| SCHEMBL4560 | 0.70 | EDNRB (0.37) | POLBEDNRBEDNRAALDH1A1CYP2C9 | |
| SCHEMBL4107 | 0.69 | EDNRB (0.36) | POLBBRD4EDNRBEDNRAALDH1A1 | |
| SCHEMBL6838 | 0.69 | L3MBTL1 (0.40) | LPAR1LPAR3BRD4BRD2BRD3 | |
| SCHEMBL1807 | 0.69 | MEN1 (0.44) | BRD4ALDH1A1LMNATDP1 | |
| SCHEMBL1166 | 0.68 | LPAR1 (0.47) | LPAR1LPAR3EDNRBEDNRAALDH1A1 | |
| SCHEMBL7770 | 0.68 | ALDH1A1 (0.53) | POLBLPAR1LPAR3ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |