Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 6/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24791589 | 0.87 | MEN1 (0.56) | HIF1AEPAS1PKMTSHRMAPK1 | |
| SCHEMBL7205562 | 0.87 | TSHR (0.51) | HIF1AEPAS1TSHRMAPK1POLB | |
| SCHEMBL7204676 | 0.81 | ALDH1A1 (0.77) | TSHRMAPK1POLBALDH1A1MAPT | |
| SCHEMBL26483278 | 0.80 | MEN1 (0.59) | PKMTSHRALDH1A1HTTMEN1 | |
| SCHEMBL4177072 | 0.78 | ALDH1A1 (0.68) | TSHRMAPK1POLBALDH1A1MAPT | |
| SCHEMBL7206100 | 0.78 | L3MBTL1 (0.76) | HIF1AEPAS1TSHRMAPK1POLB | |
| SCHEMBL7204252 | 0.75 | MAPT (0.72) | TSHRMAPK1POLBALDH1A1MAPT | |
| SCHEMBL7417394 | 0.75 | PDE4A (0.79) | TSHRALDH1A1MAPTHTTPDE4A | |
| SCHEMBL28851909 | 0.74 | HIF1A (0.40) | HIF1AEPAS1PKMTSHRMAPK1 | |
| SCHEMBL4176914 | 0.74 | PDE4D (0.61) | TSHRMAPK1POLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | claimed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | claimed |
| EP-1045690-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999026616-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1999-06-03 | — | — | WO | claimed |
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | disclosed |