Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11394681 | 0.92 | ACHE (0.67) | ACHEEPHX1 | |
| SCHEMBL22556158 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL22556148 | 0.85 | ACHE (0.50) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL28178050 | 0.84 | ACHE (0.67) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL970930 | 0.83 | ACHE (0.64) | ACHEEPHX1ALDH1A1ATM | |
| SCHEMBL11411528 | 0.83 | ACHE (0.64) | ACHEEPHX1ALDH1A1ATM | |
| SCHEMBL8195570 | 0.81 | ACHE (0.53) | ACHEEPHX1ALDH1A1ATM | |
| SCHEMBL8381680 | 0.81 | ACHE (0.74) | ACHEEPHX1ALDH1A1 | |
| SCHEMBL606986 | 0.81 | ACHE (0.62) | ACHEEPHX1ALDH1A1ATM | |
| SCHEMBL10939707 | 0.81 | ACHE (0.81) | ACHEEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38333-E1 | Making tenofovir analogs and salts; use as viricides for HIV, retroviruses | GILEAD SCIENCES, INC. | 2003-11-25 | — | — | US | disclosed |
| EP-0915894-B1 | NUCLEOTIDE ANALOGS | GILEAD SCIENCES INC (US) | 2003-05-14 | — | — | EP | disclosed |
| US-6069249-A | CHEMICAL INTERMEDIATES; DETECTION LABELS FOR NUCLEOTIDE PROBES | GILEAD SCIENCES, INC. (US) | 2000-05-30 | — | — | US | disclosed |
| US-6043230-A | Use of tenofovir disoproxil fumarate in treatment of HIV | GILEAD SCIENCES, INC. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5977089-A | ORALLY ADMINISTERING TENOFOVIR DERIVATIVES | GILEAD SCIENCES, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5922695-A | COMPOUNDS CONTAINING CARBONATE OR CARBAMATE GROUPS | GILEAD SCIENCES, INC. (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0915894-A1 | NUCLEOTIDE ANALOGS | GILEAD SCIENCES, INC. (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004569-A1 | NUCLEOTIDE ANALOGS | GILEAD SCIENCES, INC. (US) | 1998-02-05 | — | — | WO | disclosed |