SCHEMBL7206727

SCHEMBL7206727

CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1O[C@@H]1C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.59
CAPN1 P07384 8/20 0.52
CTSB P07858 2/20 0.52
CAPN9 O14815 1/20 0.52
MAPK1 P28482 1/20 0.52
POLB P06746 1/20 0.50
CHRNB2 P17787 1/20 0.47
CHRNB4 P30926 1/20 0.47
CHRNA3 P32297 1/20 0.47
CHRNA4 P43681 1/20 0.47
CTSS P25774 3/20 0.46
CTSK P43235 2/20 0.46
MMP2 P08253 1/20 0.46
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
BCHE P06276 1/20 0.45
CTSL P07711 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8349149 1.00 L3MBTL1 (0.59) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL7206720 1.00 L3MBTL1 (0.59) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL7762722 0.89 KMT2A (0.54) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL7762733 0.89 KMT2A (0.54) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL7207282 0.89 KMT2A (0.54) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL8348444 0.89 KMT2A (0.54) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL7207278 0.89 KMT2A (0.54) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL8343183 0.89 KMT2A (0.54) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL9089190 0.88 CAPN1 (0.49) L3MBTL1CAPN1CTSBCAPN9MAPK1
SCHEMBL7761860 0.88 CAPN1 (0.58) L3MBTL1CAPN1CTSBPOLBMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0921122-B1 EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF TAIHO PHARMACEUTICAL CO LTD (JP) 2003-05-21 EP disclosed
EP-0808839-B1 EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF, AND DRUGS CONTAINING THE SAME TAIHO PHARMACEUTICAL CO LTD (JP) 2001-05-23 EP disclosed
US-6110967-A USEFUL AS AGENTS FOR PREVENTING AND TREATING METABOLIC OSTEOPATHY SUCH AS OSTEOPOROSIS, HYPERCALCEMIA AND BONE METASTASIS OF CANCER BECAUSE THEY SPECIFICALLY INHIBITS CATHEPSIN L AND ITS FAMILY ENZYMES TO INHIBIT BONE RESORPTION TAIHO PHARMACEUTICALS CO., LTD. (JP) 2000-08-29 US disclosed
EP-0921122-A1 NOVEL EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) 1999-06-09 EP disclosed
EP-0808839-A1 EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF, AND DRUGS CONTAINING THE SAME TAIHO PHARMACEUTICAL CO., LTD. (JP) 1997-11-26 EP disclosed