SCHEMBL7207073

SCHEMBL7207073

C[C@@H](N)CC(=O)OCc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC15A1 P46059 2/20 0.63
ALDH1A1 P00352 3/20 0.58
MAPK1 P28482 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
MMP9 P14780 1/20 0.49
KMT2A Q03164 2/20 0.49
SLC6A2 P23975 2/20 0.49
SLC6A3 Q01959 2/20 0.49
TDP1 Q9NUW8 1/20 0.49
CDC25B P30305 1/20 0.48
SLC1A3 P43003 2/20 0.46
SLC1A2 P43004 2/20 0.46
SLC1A1 P43005 2/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
TSHR P16473 1/20 0.46
ABCB1 P08183 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL84418 1.00 SLC15A1 (0.63) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
SCHEMBL6566591 1.00 SLC15A1 (0.63) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
Sulfuric Acid SCHEMBL2424723 0.94 SLC15A1 (0.58) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
Sulfuric Acid SCHEMBL2424724 0.94 SLC15A1 (0.58) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
SCHEMBL22596734 0.87 SLC15A1 (0.58) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
SCHEMBL10140619 0.87 SLC15A1 (0.58) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
SCHEMBL28209173 0.87 SLC15A1 (0.60) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
SCHEMBL111390 0.86 ALDH1A1 (0.61) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
SCHEMBL14194794 0.85 SLC15A1 (0.58) SLC15A1ALDH1A1MAPK1L3MBTL1MMP9
Hydrochloric Acid SCHEMBL19511476 0.84 ALDH1A1 (0.59) SLC15A1ALDH1A1MAPK1L3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1912972-B1 SUBSTITUTED IMIDAZOLE COMPOUNDS AS KSP INHIBITORS NOVARTIS AG (CH) 2011-09-28 EP disclosed
CN-101558049-A Substituted pyrazole and triazole compounds as KSP inhibitors NOVARTIS AG (CH) 2009-10-14 CN disclosed
CN-101253167-A Substituted imidazole compounds as KSP inhibitors NOVARTIS VACCINES & DIAGNOSTIC (CH) 2008-08-27 CN disclosed
EP-1082302-B1 A VLA-4 INHIBITOR: OMEPUPA-V BIOGEN INC (US) 2003-12-17 EP disclosed
US-6495525-B1 N-((4-(((2-METHYLPHENYLAMINO)CARBONYL)AMINO)PHENYL)ACETYL)-L -PROLYL-3-METHYL)-BETA-ALANINE; VERY LATE ANTIGEN-4 CELL ADHESION INHIBITOR; INFLAMMATION AND IMMUNE REACTIONS BIOGEN, INC. 2002-12-17 US disclosed
EP-1082302-A1 A VLA-4 INHIBITOR: OMEPUPA-V BIOGEN, INC. (US) 2001-03-14 EP disclosed
EP-0755374-B1 PROCESS FOR PEPTIDE SEGMENT CONDENSATION MERCK & CO INC (US) 2000-08-16 EP disclosed
WO-1999061421-A1 A NOVEL VLA-4 INHIBITOR: oMePUPA-V BIOGEN, INC. (US) 1999-12-02 WO disclosed
EP-0866705-A4 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 1999-03-03 EP disclosed
US-5852045-A Fibrinogen receptor antagonists MERCK & CO., INC. (US) 1998-12-22 US disclosed
EP-0866705-A1 FIBRINOGEN RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-09-30 EP disclosed
EP-0755374-A4 PROCESS FOR PEPTIDE SEGMENT CONDENSATION MERCK & CO INC (US) 1998-09-16 EP disclosed
EP-0445796-B1 Derivatives of acetic acid containing peptide bonds HOFFMANN LA ROCHE (CH) 1998-06-17 EP disclosed
WO-1997014417-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1997-04-24 WO disclosed
EP-0755374-A1 PROCESS FOR PEPTIDE SEGMENT CONDENSATION Merck & Co., Inc. (a New Jersey corp.) (US) 1997-01-29 EP disclosed
WO-1995027727-A2 PROCESS FOR PEPTIDE SEGMENT CONDENSATION MERCK & CO., INC. (US) 1995-10-19 WO disclosed
US-5430024-A Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation HOFFMANN-LA ROCHE INC. (US) 1995-07-04 US disclosed
US-5273982-A An amidinoaryleneamidoalkylpiperazinyleneacetic acid HOFFMANN-LA ROCHE INC. (US) 1993-12-28 US disclosed
EP-0445796-A2 Derivatives of acetic acid F. HOFFMANN-LA ROCHE AG (CH) 1991-09-11 EP disclosed