Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899077 | 0.91 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1KDM4EHSD17B10LMNA | |
| SCHEMBL7208245 | 0.91 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1KDM4EHSD17B10LMNA | |
| SCHEMBL9637790 | 0.90 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KDM4EHSD17B10LMNA | |
| SCHEMBL8028102 | 0.89 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KDM4EHSD17B10LMNA | |
| SCHEMBL26931966 | 0.81 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1HSD17B10LMNAGAA | |
| SCHEMBL11477925 | 0.80 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1KDM4EHSD17B10LMNA | |
| SCHEMBL7207409 | 0.79 | NPSR1 (0.36) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL11267533 | 0.78 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KDM4EHSD17B10ALOX15 | |
| SCHEMBL28098155 | 0.77 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1KDM4EHSD17B10NPSR1 | |
| SCHEMBL8277962 | 0.77 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1KDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2995615-A1 | CYCLOPROPYL-FUSED PYRROLIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND THEIR PHARMACEUTICAL USE | AstraZeneca AB (SE) | 2016-03-16 | — | — | EP | disclosed |
| EP-2272825-B1 | Protected amino hydroxy adamantane carboxylic acid and process for its preparation | ASTRAZENECA AB (SE) | 2015-11-04 | — | — | EP | disclosed |
| EP-1559710-B1 | Dipeptidyl peptidase IV inhibitors based on cyclopropyl-fused pyrrolidine, process for their preparation and their use | BRISTOL MYERS SQUIBB CO (US) | 2014-02-26 | — | — | EP | disclosed |
| US-RE44186-E1 | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-30 | — | — | US | disclosed |
| EP-2272825-A2 | N-Protected amino hydroxy adamantane carboxylic acid and process for its preparation | Bristol-Myers Squibb Company (US) | 2011-01-12 | — | — | EP | disclosed |
| EP-1261586-B1 | CYCLOPROPYL-FUSED PYRROLIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV, PROCESSES FOR THEIR PREPARATION, AND THEIR USE | BRISTOL MYERS SQUIBB CO (US) | 2008-05-21 | — | — | EP | disclosed |
| US-6613934-B1 | Enzymatic partial hydrolysis of a diester of malonic acid | DEGUSSA AG (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-0812819-B1 | Enantiomer-enriched tertiary hydrocarbonrest-substituted malonic acid ester and the preparation | DEGUSSA (DE) | 2001-11-28 | — | — | EP | disclosed |
| EP-0812819-A2 | Enantiomer-enriched tertiary hydrocarbonrest-substituted malonic acid ester and the preparation | HÜLS AKTIENGESELLSCHAFT (DE) | 1997-12-17 | — | — | EP | disclosed |