SCHEMBL7207537

SCHEMBL7207537

COC(=O)Oc1ccc[nH]1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.42
HSD17B10 Q99714 2/20 0.42
HPGD P15428 1/20 0.42
KMT2A Q03164 3/20 0.39
GAA P10253 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
BLM P54132 2/20 0.39
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
NR4A2 P43354 1/20 0.36
CREBBP Q92793 1/20 0.36
CYP1A2 P05177 3/20 0.35
CYP2D6 P10635 3/20 0.35
CYP1A1 P04798 2/20 0.35
NAPRT Q6XQN6 1/20 0.34
P2RX4 Q99571 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17223652 0.87 NAPRT (0.39) KDM4EKMT2AGAAL3MBTL1BLM
SCHEMBL3812449 0.79
SCHEMBL127155 0.77
Hydroxyamine SCHEMBL27542818 0.76 SLC22A6 (0.40) KDM4EHSD17B10HPGDKMT2AGAA
SCHEMBL9481833 0.76 KDM4E (0.36) KDM4EKMT2AGAAL3MBTL1BLM
SCHEMBL4039811 0.75
SCHEMBL5159365 0.75
SCHEMBL4601907 0.74 ACHE (0.44) KDM4EKMT2AGAAL3MBTL1BLM
SCHEMBL28944159 0.74 NAPRT (0.31) KDM4EGAAMAPTNAPRT
SCHEMBL27483435 0.74 RAB9A (0.42) KDM4EHPGDKMT2AGAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0434070-B1 Pyrrolealdehyde derivative MITSUBISHI CHEM CORP (JP) 1995-08-09 EP claimed
EP-0923546-B1 ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A2 MERCKLE GMBH (DE) 2003-11-26 EP disclosed
EP-0923546-A1 ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A2 Merckle GmbH (DE) 1999-06-23 EP disclosed
WO-1998005637-A1 ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A¿2? MERCKLE GMBH (DE) 1998-02-12 WO disclosed
EP-0021207-B1 ALPHACARBAMOYL-PYRROLPROPIONITRILES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM CIBA-GEIGY AG (CH) 1985-08-07 EP disclosed
EP-0143142-A2 Alpha-carbamoyl-pyrrolepropionitriles, process for their preparation, pharmaceutical preparations containing them and their uses in therapeutic applications CIBA-GEIGY AG (CH) 1985-06-05 EP disclosed
EP-0021207-A1 Alphacarbamoyl-pyrrolpropionitriles, process for their preparation and pharmaceutical preparations containing them CIBA-GEIGY AG (CH) 1981-01-07 EP disclosed