Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899986 | 0.80 | TRPA1 (0.38) | TRPA1CYP2C19IDO1NFE2L2ALDH1A1 | |
| SCHEMBL2844260 | 0.78 | TRPA1 (0.37) | TRPA1CYP2C19NFE2L2ALDH1A1TSHR | |
| SCHEMBL28886988 | 0.72 | ESR1 (0.31) | MAPK1 | |
| SCHEMBL28495781 | 0.71 | BACE1 (0.36) | IDO1ALDH1A1CYP2A6MEN1KMT2A | |
| SCHEMBL9699570 | 0.69 | TRPA1 (0.53) | TRPA1MAPK1CYP2C19ALDH1A1HSP90AA1 | |
| SCHEMBL6111605 | 0.69 | TDP1 (0.38) | TDP1TRPA1MAPK1CYP2C19NFE2L2 | |
| SCHEMBL7395928 | 0.68 | IDO1 (0.55) | IDO1MAOBMEN1KMT2AHSD17B10 | |
| SCHEMBL7395933 | 0.68 | IDO1 (0.55) | IDO1MAOBMEN1KMT2AHSD17B10 | |
| SCHEMBL29566039 | 0.68 | IDO1 (0.55) | IDO1MAOBMEN1KMT2AHSD17B10 | |
| SCHEMBL2368966 | 0.67 | PREP (0.45) | MAPK1ALDH1A1TSHRHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992004327-A1 | ANTIVIRAL COMPOUNDS AND ANTIHYPERTENSIVE COMPOUNDS | SCHERING CORPORATION (US) | 1992-03-19 | — | — | WO | claimed |
| EP-1044204-B1 | PROCESS FOR THE PREPARATION OF ALPHA-OXOLACTAMS | RES CORP TECHNOLOGIES INC (US) | 2003-06-04 | — | — | EP | disclosed |
| US-6255479-B1 | REACTING AN ALPHA-DIAZOLACTAM WITH AN EPOXIDE, IN THE PRESENCE OF A TRANSITION METAL CATALYST (OF RHODIUM, COPPER, OR RHENIUM), YIELDS ALPHA-OXOLACTAM | RESEARCH CORPORATION TECHNOLOGIES, INC. | 2001-07-03 | — | — | US | disclosed |
| EP-1044204-A1 | PROCESS FOR THE PREPARATION OF ALPHA-OXOLACTAMS | Research Corporation Technologies, Inc (US) | 2000-10-18 | — | — | EP | disclosed |
| US-5942522-A | 1-BENZYL-3-ETHOXYCARBONYL-4-DIMETHYLAMINOETHOXY-6-METHYL-2-(1H) -QUINOLINONE; ANTIVIRAL AGAINST DNA CONTAINING VIRUSES, SUCH AS HERPES GROUP VIRUSES | SCHERING CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |
| WO-1999033837-A1 | PROCESS FOR THE PREPARATION OF α-OXOLACTAMS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1999-07-08 | — | — | WO | disclosed |