Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204440 | 0.84 | SLC6A4 (0.66) | SLC6A4 | |
| SCHEMBL7208611 | 0.81 | SLC6A4 (0.59) | SLC6A4 | |
| SCHEMBL7205038 | 0.80 | SLC6A4 (0.65) | SLC6A4 | |
| SCHEMBL7202266 | 0.79 | SLC6A4 (0.63) | SLC6A4 | |
| SCHEMBL7201252 | 0.78 | SLC6A4 (0.55) | SLC6A4 | |
| SCHEMBL7201460 | 0.77 | SLC6A4 (0.58) | SLC6A4 | |
| SCHEMBL7206081 | 0.76 | SLC6A4 (0.52) | SLC6A4 | |
| SCHEMBL7207614 | 0.76 | SLC6A4 (0.59) | SLC6A4 | |
| SCHEMBL7201730 | 0.75 | SLC6A4 (0.54) | SLC6A4 | |
| Acetic Acid SCHEMBL7207801 | 0.75 | SLC6A4 (0.63) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |