Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207869 | 0.86 | NPC1 (0.46) | NPC1RAB9ACTSKCTSLCTSS | |
| SCHEMBL7209082 | 0.86 | NPC1 (0.46) | NPC1RAB9ACTSKCTSLCTSS | |
| SCHEMBL7212770 | 0.85 | CTSK (0.46) | NPC1RAB9ACTSKCTSLCTSS | |
| SCHEMBL7212869 | 0.85 | CTSK (0.46) | NPC1RAB9ACTSKCTSLCTSS | |
| SCHEMBL7214212 | 0.82 | NPC1 (0.47) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL4265208 | 0.82 | NPC1 (0.47) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL11188226 | 0.82 | CTSK (0.46) | NPC1RAB9ACTSKCA1CA2 | |
| SCHEMBL7214128 | 0.81 | NPC1 (0.53) | NPC1RAB9A | |
| SCHEMBL7212923 | 0.80 | NPC1 (0.44) | NPC1RAB9ACTSKCTSLCTSS | |
| SCHEMBL7208522 | 0.80 | NPC1 (0.44) | NPC1RAB9ACTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150988-B1 | PHOSPHORAMIDATE, AND MONO-, DI-, AND TRI-PHOSPHATE ESTERS OF (1R, CIS)-4-(6-AMINO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL AS ANTIVIRAL AGENTS | GLAXO GROUP LTD (GB) | 2003-05-28 | — | — | EP | claimed |