Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 3/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207869 | 1.00 | NPC1 (0.46) | NPC1RAB9ATACR1MMEECE1 | |
| SCHEMBL7214128 | 0.92 | NPC1 (0.53) | NPC1RAB9AANPEP | |
| SCHEMBL7212742 | 0.87 | HPRT1 (0.39) | LAP3ANPEPCTSL | |
| SCHEMBL28460302 | 0.87 | TACR1 (0.43) | NPC1RAB9ATACR1MMEECE1 | |
| SCHEMBL7212770 | 0.86 | CTSK (0.46) | NPC1RAB9ACTSLCTSBCTSS | |
| SCHEMBL7207876 | 0.86 | NPC1 (0.43) | NPC1RAB9ACTSLCTSSCTSK | |
| SCHEMBL7212869 | 0.86 | CTSK (0.46) | NPC1RAB9ACTSLCTSBCTSS | |
| SCHEMBL7214212 | 0.83 | NPC1 (0.47) | NPC1RAB9A | |
| SCHEMBL4265208 | 0.83 | NPC1 (0.47) | NPC1RAB9A | |
| SCHEMBL7212740 | 0.83 | ECE1 (0.55) | TACR1MMEECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150988-B1 | PHOSPHORAMIDATE, AND MONO-, DI-, AND TRI-PHOSPHATE ESTERS OF (1R, CIS)-4-(6-AMINO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL AS ANTIVIRAL AGENTS | GLAXO GROUP LTD (GB) | 2003-05-28 | — | — | EP | claimed |