Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713440 | 0.92 | TLR2 (0.57) | TLR2KMT2APTPN1TNFCASP3 | |
| SCHEMBL30434908 | 0.92 | TLR2 (0.57) | TLR2KMT2APTPN1TNFCASP3 | |
| SCHEMBL27093964 | 0.88 | TLR2 (0.62) | TLR2KMT2APTPN1TNFCASP3 | |
| SCHEMBL27093960 | 0.88 | TLR2 (0.62) | TLR2KMT2APTPN1TNFCASP3 | |
| SCHEMBL38664780 | 0.86 | TLR2 (0.54) | TLR2KMT2APTPN1TNFCASP3 | |
| SCHEMBL30919288 | 0.84 | KMT2A (0.54) | TLR2KMT2APTPN1CASP3MDM2 | |
| SCHEMBL17826082 | 0.83 | KMT2A (0.56) | TLR2KMT2APTPN1CASP3MDM2 | |
| SCHEMBL12928621 | 0.83 | KMT2A (0.56) | TLR2KMT2APTPN1CASP3MDM2 | |
| SCHEMBL13658468 | 0.83 | KMT2A (0.56) | TLR2KMT2APTPN1CASP3MDM2 | |
| SCHEMBL29400679 | 0.83 | KMT2A (0.56) | TLR2KMT2APTPN1CASP3MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871464-B1 | BRADYKININ ANALOGS AS SELECTIVE THROMBIN INHIBITORS | UNIV MICHIGAN (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-0871464-A4 | BRADYKININ ANALOGS AS SELECTIVE THROMBIN INHIBITORS | UNIV MICHIGAN (US) | 2001-05-16 | — | — | EP | disclosed |
| US-6143719-A | INHIBITING THROMBIN-INDUCED CELL ACTIVATION MEDIATED BY THROMBIN RECEPTOR BY INHIBITING CLEAVAGE OF THROMBIN RECEPTOR ON CELLS BY ADMINISTERING PEPTIDE | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0871464-A1 | BRADYKININ ANALOGS AS SELECTIVE THROMBIN INHIBITORS | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1996041640-A1 | BRADYKININ ANALOGS AS SELECTIVE THROMBIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-12-27 | — | — | WO | disclosed |