Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.48 |
| ▸ | RARB | P10826 | 9/20 | 0.48 |
| ▸ | RARG | P13631 | 5/20 | 0.48 |
| ▸ | RARA | P10276 | 5/20 | 0.48 |
| ▸ | RXRB | P28702 | 3/20 | 0.44 |
| ▸ | RXRG | P48443 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208507 | 1.00 | RXRA (0.48) | RXRARARBRARGRARARXRB | |
| SCHEMBL7212209 | 0.96 | RXRA (0.53) | RXRARARBRARGRARARXRB | |
| SCHEMBL7212216 | 0.96 | RXRA (0.53) | RXRARARBRARGRARARXRB | |
| SCHEMBL7208752 | 0.92 | RARB (0.53) | RXRARARBRARGRARARXRB | |
| SCHEMBL7208758 | 0.92 | RARB (0.53) | RXRARARBRARGRARARXRB | |
| SCHEMBL7212228 | 0.88 | RARB (0.63) | RXRARARBRARGRARARXRB | |
| SCHEMBL7212226 | 0.88 | RARB (0.63) | RXRARARBRARGRARARXRB | |
| SCHEMBL10842696 | 0.88 | RARB (0.63) | RXRARARBRARGRARARXRB | |
| SCHEMBL4669367 | 0.88 | RARB (0.63) | RXRARARBRARGRARARXRB | |
| SCHEMBL4669370 | 0.88 | RARB (0.63) | RXRARARBRARGRARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | claimed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | claimed |
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |