Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19996369 | 0.87 | SLC6A2 (0.50) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL8776566 | 0.85 | S1PR1 (0.49) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL9747402 | 0.85 | S1PR1 (0.49) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL15312357 | 0.83 | S1PR1 (0.48) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL28830783 | 0.83 | S1PR1 (0.47) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL7122292 | 0.82 | S1PR1 (0.46) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL27473293 | 0.81 | SLC6A2 (0.42) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL566352 | 0.79 | MLNR (0.61) | HTR2ASLC6A2SLC6A4HTR2CDRD2 | |
| SCHEMBL7208032 | 0.79 | PRKCG (0.37) | SLC6A2SLC6A4HTR2CS1PR1ESR1 | |
| SCHEMBL7212153 | 0.79 | HTR2A (0.40) | HTR2ASLC6A2SLC6A4HTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| US-5700836-A | TOPICALLY ADMINISTERING TO TREAT PHOTODAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1997-12-23 | — | — | US | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |